Was discussed by JD and Brownie last night. No pitcher has ever had this 22-1 record before, though one did have a 33-3 against a team.
Warning: WikiCrapia reference coming.
Roy O's .957 winning % (22-1) against the Reds is by far the highest.
Carl Mays is second, with a .921 winning % (35-3) against the Philadelphia Athletics.
"Oswalt is the first pitcher ever to begin his career by going 22-1 against another team. Three other pitchers began 20-1, but each then lost his 22nd decision: Charley Radbourn against the Phillies, and Larry Jackson and Juan Marichal both against the Mets."