The Astros are in an interesting position now with their 40-man with some talented players being on that bubble where they, barring injury to a starter, won't be on the 25-man and have accomplished about all they need to in the high minors. Reed, Moran, Teo Hernandez, White, Stassi. Brady Rodgers among pitchers. I don't remember a time with so many ML ready guys not being able to make the roster because of numerical limitations. It will be interesting to see how Luhnow manages this.
Edit: add Kemp to the list.